Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction
نویسندگان
چکیده
منابع مشابه
Intrauterine calorie restriction affects placental DNA methylation and gene expression.
Maternal nutrient restriction causes the development of adult onset chronic diseases in the intrauterine growth restricted (IUGR) fetus. Investigations in mice have shown that either protein or calorie restriction during pregnancy leads to glucose intolerance, increased fat mass, and hypercholesterolemia in adult male offspring. Some of these phenotypes are shown to persist in successive genera...
متن کاملPlacental Nutrient Transport and Intrauterine Growth Restriction
Intrauterine growth restriction refers to the inability of the fetus to reach its genetically determined potential size. Fetal growth restriction affects approximately 5-15% of all pregnancies in the United States and Europe. In developing countries the occurrence varies widely between 10 and 55%, impacting about 30 million newborns per year. Besides having high perinatal mortality rates these ...
متن کاملIntrauterine growth restriction and placental angiogenesis
BACKGROUND Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (b-FGF), and endothelial nitric oxide synthase (eNOS) are factors that take part in placental angiogenesis. They are highly expressed during embryonic and fetal development, especially in the first trimester. In this study, we aimed to investigate the role of placental angiogenesis in the development of intraut...
متن کاملPlacental changes in idiopathic intrauterine growth restriction
Abstract Introduction Placenta is the maternal–foetal contact zone. The placentas of ‘idiopathic’ intrauterine growth retardation babies may hold the key to the aetiology of growth restriction. It was noted by most workers that in cases of intrauterine growth retardation placentas, there were some abnormal positions of insertion of umbilical cords, placental weight and volume was significantly ...
متن کاملPlacental mitochondrial content and function in intrauterine growth restriction and preeclampsia.
Intrauterine growth restriction (IUGR) and pregnancy hypertensive disorders such as preeclampsia (PE) associated with IUGR share a common placental phenotype called "placental insufficiency", originating in early gestation when high availability of energy is required. Here, we assess mitochondrial content and the expression and activity of respiratory chain complexes (RCC) in placental cells of...
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ژورنال
عنوان ژورنال: Gynecology Obstetrics & Reproductive Medicine
سال: 2020
ISSN: 2602-4918,1300-4751
DOI: 10.21613/gorm.2019.969